Toward a Predictive Theory of Depression

Corlett, Frith and Fletcher linked mania to increased confidence. But mania looks a lot like being happy. And you’re happy when you succeed a lot. And when you succeed a lot, maybe having increased confidence is the way to go. If happiness were a sort of global filter that affected all your thought processes and said “These are good times, you should press really hard to exploit your apparent excellence and not worry too much about risk”, that would be pretty evolutionarily useful. Likewise, if sadness were a way of saying “Things are going pretty badly, maybe be less confidence and don’t start any new projects”, that would be useful too.

Depression isn’t normal sadness. But if normal sadness lowers neural confidence a little, maybe depression is the pathological result of biological processes that lower neural confidence. To give a total fake example which I’m not saying is what actually happens, if you run out of whatever neurotransmitter you use to signal high confidence, that would give you permanent pathological low confidence and might look like depression.

The Nashville Statement Is an Attack on L.G.B.T. Christians

The Nashville Statement, released by the Council on Biblical Manhood and Womanhood on Tuesday, says that only heterosexuality is permissible, calls people born with intersex conditions “disordered,” derides transgender identities as “transgenderism” and makes clear that anyone who is an L.G.B.T. person is immoral.

.. The statement can’t be written off as the regressive stance of a fringe group: More than 150 influential conservative evangelical leaders, half of whom belong to the Southern Baptist Convention, signed the statement. Steve Gaines, president of the Southern Baptist Convention, and James Dobson, founder of Focus on the Family and member of Donald Trump’s faith advisory board, endorsed it. Russell Moore, president of the Southern Baptist Convention’s public policy arm, also signed on. Presidents of seminaries, editors and writers at the largest conservative publications, as well as presidents and directors of conservative think tanks added their names.

.. L.G.B.T. youths have disproportionately high rates of suicide and of anxiety and depression — problems that are undoubtedly worsened by the condemnation of those who hold beliefs like the ones in the Nashville Statement. Those whose families reject them, most of whom are from religious backgrounds, are 8.4 times more likely to attempt suicide than their straight peers. L.G.B.T. youths also suffer from high rates of homelessness. Because of conservative churches’ teachings about sexuality, some parents prefer their L.G.B.T. children sleep on the streets instead of in their homes.

.. Evangelicals’ promotion of “reparative therapy” that tries to change L.G.B.T. people’s sexual orientation or gender identity, which has been condemned by every major medical organization, has also brought harm and death.

.. More broadly, the type of theology underlying the Nashville Statement is used to defend the denial of goods and services to same-sex couples. The political power evangelicals hold in the United States allows them to codify their beliefs in law.

Have Smartphones Destroyed a Generation?

More comfortable online than out partying, post-Millennials are safer, physically, than adolescents have ever been. But they’re on the brink of a mental-health crisis.

.. She told me she’d spent most of the summer hanging out alone in her room with her phone. That’s just the way her generation is, she said. “We didn’t have a choice to know any life without iPads or iPhones. I think we like our phones more than we like actual people.”

.. The biggest difference between the Millennials and their predecessors was in how they viewed the world; teens today differ from the Millennials not just in their views but in how they spend their time. The experiences they have every day are radically different from those of the generation that came of age just a few years before them.

.. the more I talked with young people like Athena, the clearer it became that theirs is a generation shaped by the smartphone and by the concomitant rise of social media. I call them iGen. Born between 1995 and 2012, members of this generation are growing up with smartphones, have an Instagram account before they start high school, and do not remember a time before the internet.

.. the allure of independence, so powerful to previous generations, holds less sway over today’s teens, who are less likely to leave the house without their parents. The shift is stunning: 12th-graders in 2015 were going out less often than eighth-graders did as recently as 2009.

.. Today’s teens are also less likely to date.

.. The decline in dating tracks with a decline in sexual activity. The drop is the sharpest for ninth-graders, among whom the number of sexually active teens has been cut by almost 40 percent since 1991. The average teen now has had sex for the first time by the spring of 11th grade, a full year later than the average Gen Xer.

.. Even driving, a symbol of adolescent freedom inscribed in American popular culture, from Rebel Without a Cause to Ferris Bueller’s Day Off, has lost its appeal for today’s teens.

.. In conversation after conversation, teens described getting their license as something to be nagged into by their parents—a notion that would have been unthinkable to previous generations.

.. It’s not an exaggeration to describe iGen as being on the brink of the worst mental-health crisis in decades. Much of this deterioration can be traced to their phones.

.. In an information economy that rewards higher education more than early work history, parents may be inclined to encourage their kids to stay home and study rather than to get a part-time job. Teens, in turn, seem to be content with this homebody arrangement—not because they’re so studious, but because their social life is lived on their phone. They don’t need to leave home to spend time with their friends.

.. But eighth-, 10th-, and 12th-graders in the 2010s actually spend less time on homework than Gen X teens did in the early 1990s. (High-school seniors headed for four-year colleges spend about the same amount of time on homework as their predecessors did.) The time that seniors spend on activities such as student clubs and sports and exercise has changed little in recent years. Combined with the decline in working for pay, this means iGen teens have more leisure time than Gen X teens did, not less.
.. Teens who spend more time than average on screen activities are more likely to be unhappy, and those who spend more time than average on nonscreen activities are more likely to be happy.

.. The more time teens spend looking at screens, the more likely they are to report symptoms of depression.

Ketamine: The Future of Depression Treatment?

Treatment then consists of six infusions over 12 days. Each infusion lasts about 45 minutes. Side effects, which often include confusion, lucid daydreaming, and fuzzy vision, clear up quickly. Patients are watched closely and must have pre-arranged transport home. They’re barred from driving or using heavy machinery for 24 hours.

Abreu says in his experience, the side effects “go away as soon as the infusion is over, and patients don’t have hallucinations.”

Abreu says about three quarters of his patients aged 15 to 55 benefit from ketamine. Older patients have a lower response rate. The initial six infusions cost $3,800, the beneficial effects of which last anywhere from 3 to 5 weeks for some patients, and up to 12 weeks for others. Patients return as needed for single boosters, which cost $600. Because the FDA has not approved ketamine for this use, insurance doesn’t cover it.