How an Engineering Student’s Question Prevented a NYC Skyscraper from Falling Down

Citigroup Center

Engineering crisis of 1978 (from Wikipedia)

Due to material changes during construction, the building as initially completed was structurally unsound. William LeMessurier‘s original design for the chevron load braces used welded joints. To save money, Bethlehem Steel changed the plans in 1974 to use bolted joints, which was accepted by LeMessurier’s office but not known to the engineer himself.[22] Furthermore, according to The New Yorker, LeMessurier originally only needed to calculate wind loads from perpendicular winds under the building code; in typical buildings, loads from quartering winds at the corners would be less.[22][159] In June 1978, after an inquiry from Princeton University engineering student Diane Hartley, LeMessurier recalculated the wind loads on the building with quartering winds.[159][f] He found that, for four of the eight tiers of chevrons, such winds would create a 40 percent increase in wind loads and a 160 percent increase in load at the bolted joints.[22]

Citicorp Center’s use of bolted joints and the increased loads from quartering winds would not have caused concern if these issues had been isolated from each other. However, the combination of the two findings prompted LeMessurier to run tests on the structural safety.[103] The original welded-joint design could withstand the load from straight-on and quartering winds, but a 75-mile-per-hour (121 km/h) hurricane force quartering wind would exceed the strength of the bolted-joint chevrons.[99] With the tuned mass damper active, LeMessurier estimated that a wind capable of toppling the building would occur on average once every 55 years.[162][161] If the tuned mass damper could not function due to a power outage, a wind strong enough to cause the building’s collapse would occur once every 16 years on average.[162] LeMessurier also discovered that his firm had used New York City’s truss safety factor of 1:1 instead of the column safety factor of 1:2.[99] [Read more…]

How a lack of legitimacy undermines “Broken Windows Policing”

In a 2011 New Yorker talk, Malcolm Gladwell described the central role “legitimacy” plays in motivating people.  Previously, political theorists had focused on “deterrence theory” that treats people as rational actors who decide whether to follow the law based upon a weighing of the pros and cons of compliance.

Protesting Illegitimate Authority

Gladwell cites NYU Professor Tom Tyler’s work on “legitimacy”, and argues that people will fight to the death and even go on hunger strikes against an authority they feel is illegitimate, despite overwhelming penalties that deterrence theorists assume would be effective.

Gladwell identifies 3 factors in establishing legitimacy:

  1. Does the authority grant one standing and listen to one’s petitions?
  2. Is authority administered with neutrality or is there one set of rules for one group and a different system for others?
  3. Is the system trustworthy — does it follow well-defined rules that are sensible and are not subject to arbitrary change?

[Read more…]

The amazing woman responsible for the Pfizer and Moderna Vaccines

Here’s the amazing story of grit and perseverance about the woman who did the pioneering work for the Pfizer and Moderna vaccine.
Katalin Kariko light corrected.jpeg
Katalin Karikó, born in Hungary
Temple University & University of Pennsylvania

Timeline: Development of Vaccine by Katalin Karikó:

(from Wired Magazine article)

  1. 1955: Katalin Karikó was born in Hungary
  2. 1976: She hears about ideas of using mRNA to target viruses while an undergrad at the University of Szegedin Hungary.
  3. She completes her Ph.D.
  4. 1985: As an immigrant from Hungary, Katalin Karikó immigrated to the US to do research at Temple University.
  5. After a dispute with her boss, Temple University tried to have her deported.
  6. She switched to the University of Pennsylvania, but her research was not considered promising because there were significant challenges in getting the immune system to accept the mRNA that the vaccine uses.
  7. The mid-1990s — She failed to get funding for her work at the University of Pennsylvania and was forced to choose between stopping work on her mRNA research or be demoted from a track to be a full professor.
  8. She chose to be demoted and continue her research.
  9. UPenn’s ultimatum was posed just after she had been diagnosed with cancer.
  10. She persisted and was able to get her research funded with the help of an established immunology professor — Drew Weissman — who she met at the photocopier.
  11. In the early 2000s: she read a study that gave her an idea of how to avoid the adverse immune system reaction that prevented mRNA from being used in vaccines.
  12. 2005: Karikó and Weissman published a study suggesting that there may be a way to avoid the immune reaction.
  13. After publishing their research and patenting it, Karikó and Weissman received no invitations to talk about their work.
  14. But Derrick Rossi, a postdoc at Stanford University noticed their research and created a company called Moderna in 2010 to commercialize the technology.
  15. Karikó and Weissman licensed their technology to a small German company called BioNTech, after five years of trying and failing.  (BioNTech was founded by a Turkish immigrant named Ugur Sahin)
  16. 2013: UPenn refused to reinstate Katalin Karikó as a full professor after demoting her in 1995. She told them she was leaving to go to BioNTech: ”When I told them I was leaving, they laughed at me and said, ‘BioNTech doesn’t even have a website.’”
  17. 2017: Moderna (founded by the Derrick Rossi Stanford postdoc) used the technology Karikó pioneered to develop a Zika virus vaccine .
  18. 2018: The German company Karikó and Weissman licensed their technology to partnered with Pfizer to develop an influenza vaccine.
  19. April 2020: Derrick Rossi’s Moderna received $483 million (£360m) from the US Biomedical Advanced Research and Development Authority to fast-track its Covid-19 vaccine program
  20. Pfizer developed their mRNA vaccine using Karikó and Weissman research, but without government funding.

Read More:

1) Read full “Wired” article: