What risks do US interests currently face in the Middle East?

Oy, this is a doozy. I think President Obama did a nice job summarizing U.S. interests in the Middle East in his speech to the UN General Assembly in 2013:
The gist of it was this:
The United States of America is prepared to use all elements of our power, including military force, to secure our core interests. . . . We will confront external aggression against our allies and partners. . . . We will ensure the free flow of energy. . . . We will dismantle terrorist networks that threaten our people. . . . And finally, we will not tolerate the development or use of weapons of mass destruction.

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