Clyde Lee Giles is an American computer scientist and the David Reese Professor at the College of Information Sciences and Technology at the Pennsylvania State University. He is also Graduate Faculty Professor of Computer Science and Engineering, Courtesy Professor of Supply Chain and Information Systems, and Director of the Intelligent Systems Research Laboratory. He was Interim Associate Dean of Research. His graduate degrees are from the University of Michigan and the University of Arizona and his undergraduate degrees are from Rhodes College and the University of Tennessee. His PhD is in optical sciences with advisor Harrison H. Barrett. His academic genealogy includes two Nobel laureates (Felix Bloch and Werner Heisenberg) and prominent mathematicians.